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Microinjection

  1. CardioPhys ECG is Perfect for Affordable Cardiotoxicity Testing in Small Animals
    May 18, 2020
    [by Mikaël Berrou] CardioPhys™ and Cardiotoxicity When a new drug is discovered with an effect against a pathology, a natural public demand would ask to administrate it immediately. Although the new drug may be beneficial in many aspects, that new molecule could potentially have side effects that need to be evaluated. The most important potential side effect is cardiotoxicity. What is Cardiotoxicity? Cardiotoxicity is the damage to the heart by harmful chemicals (www.nccn.org/patients/resources/life_with_cancer/managing_symptoms/cardiac_toxicity.aspx), and its evaluation has become the fi
  2. Versatile Microinjection Syringe Pump (UMP3T) for Injections in the Nanoliter to Milliliter Range
    May 15, 2020
    The UltraMicroPump3 is a versatile microinjection syringe pump designed to support the needs of a busy lab. Suitable for delivery of media from nanoliters to milliliters the UMP3’s user interface and system design enables delivery of highly accurate and repeatable injections. The choice for thousands of scientists, it is widely cited in research papers.   Intuitive Touchscreen Display for Easy Setup The SMARTouch controller has an intuitive touch screen interface and an easy-to-use menu for quick configuration of the syringe size, volumes and flow rates. The total system calibration is designed to eliminate human errors and reduce experimental processing t
  3. 8 Good Reasons to Choose the MICRO-ePUMP Microinjector for your Applications
    April 10, 2020
    Do you need a precision microinjcetor with an integrated pressure source for injections in the picoliter range? WPI’s new MICRO-ePUMP, which is comparable to the Ependorf Femtojet, is a portable solution for injecting DNA, RNA and proteins, as well as pre- and post- implantation in embryos. Whether you are doing disease modeling with zebrafish or viral research for SARS-CoV2, the MICRO-ePUMP has much to offer. Here are eight good reasons to choose the MICRO-ePUMP for your applications.   Convenient internal pressure source The convenient internal pressure source is designed to simplify intracellular i
  4. Genetic Transfer (viral or non-viral vector) Using Microprocessor-Controlled Injector
    March 02, 2020
    With the first approved human gene therapy trial in 19891 (Rosenberg, et.al.), gene therapy has come a long way in modern medicine and is making inroads in clinics and the market in general.2,3 2017 was an important year for gene therapy when Luxurna, the first human gene therapy drug for an inherited retinal dystrophy, was approved by Food and Drug Administration (USA).4 Now several drugs are undergoing clinical trials. With an estimated $11 billion (USD) market in the next 10 years, both clinical trials and the pharmaceutical industry are expected to benefit immensely from gene therapy.5 With improved use of viral vectors (Adeno-associated virus (AAV), adenovirus, lentivirus, retrovirus, HSV) or non-viral vectors, research and clinical trials on the development of therapeutic genes have witnessed great success. Viral vectors
  5. New Technology Makes Microinjection More Reliable, Repeatable and Affordable
    January 24, 2020
    Microinjection is the process of transferring genetic materials into a living cell using glass micropipettes or metal microinjection needles. Glass micropipettes can be of various sizes with tip diameters ranging from 0.1 to 10 µm. DNA or RNA is injected directly into the cell’s nucleus. Microinjection has been successfully used with large frog eggs, mammalian cells, mammalian embryos, plants and tissues. Microinjection has been expensive, can be a slow process and requires skilled personnel, but new technologies are making it even more reliable, repeatable and affordable. Pronuclear injection, inserting DNA or RNA into the nucleus of a fertilized oocyte to create transgenic organisms, lets researchers study the role of particular genes. This horizontal gene transfer can insert genetic material from the same species or a
  6. WPI's NanoFil: Injection of Sub-Microliter Volumes in Animal Research
    August 21, 2019
    Are you looking for a microliter or sub-microliter and high precision syringe that holds needles as small as 36 gauge (G), in addition to having the capability to connect to quartz tubing? WPI’s NanoFil is the answer. We offer NanoFil syringes with NanoFil needles or the option to connect the NanoFil syringe to quartz tubing to use in research studies, mainly involving sub-microliter volume injections into animal tissues. Why Select WPI’s NanoFil (Syringe and Needle) System? Low Dead Volume The dead volume of NanoFil's is minute or neglig
  7. Researcher Shares Video of MICRO-ePORE™ Assisted Cell Penetration
    August 02, 2019
    The new WPI MICRO-ePORE™ pinpoint cell penetrator is a simple and versatile system that can be used to facilitate microinjection of a diverse array of compounds and biomolecules into oocytes and pre-implantation stage mammalian embryos. Patent pending Flutter Electrode Technology assists in small, clean, precise membrane penetration without tearing or damaging the membrane. It results in substantially increased viability of embryos. In this quick video, Dr. Pelczar from the Center for Transgenic Models in Switzerland demonstrates the ease of cell penetration using the new MICRO-ePORE™. 
  8. Instruments for Zebrafish research - oocytes, embryos, larvae and adults
    July 23, 2019
    World Precision Instruments (WPI) offers a broad range of research instruments for zebrafish research, from the time the genetics of the subject are modified through the point where the physiological effects of the change are monitored. Whether researchers are performing microinjection or making cardiovascular measurements, the WPI product line includes instruments for research on oocytes, embryos, larvae and adult zebrafish. Enhanced microinjection efficiency for genetic modification The customizable Zebrafish Microinjection Toolbox includes components favored by researchers: SYS-PV820/SYS-PV830 Pneumatic PicoPump, PUL-1000
  9. Setting Up The MICRO-ePORE
    June 19, 2019
    The new WPI MICRO-ePORE™ Pinpoint Cell Penetrator is a simple and versatile system that can be used for efficient microinjection of a diverse array of compounds and biomolecules into oocytes and pre-implantation stage mammalian embryos. Patent pending Flutter Electrode Technology assists in small, clean, precise membrane penetration without tearing or damaging the membrane. Here Gabe sets up the system and connects all the components. Unpacking Your MICRO-ePORE™ System Connecting Your MICRO-ePORE™ System Connecting the MICRO-ePORE™ Electrode Holders
  10. Using the 900A Micropressure System for Measuring Pressure in Small Blood Vessels and Cells
    July 16, 2018
    This 900A video series of 6 videos is designed to help familiarize you with the basic operation of the 900A Micropressure System. The 900A was designed for measuring pressures in kidney tubules, and it has many applications. It has recently been used for measuring ventricular blood pressure in larval fish. We suggest that you become familiar with the information in the instruction manual and the parts and techniques you need to operate the system effectively. Please read the manual and watch these videos prior to setting up and testing your 900A Micropressure System.  Instrument Description The 900A Micropressure System is designed to measure pressures from –200 to +400 mmHg in sma
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